BIOL 430 2010 lecture 11 handout

BIOL 430 2010 lecture 11 handout - BIOL 430 Lecture 11...

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BIOL 430 Lecture 11 February 3 rd 2010 Development of the Drosophila body plan Maternal genes A-P and D-V patterning BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Drosophila melanogaster BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 2.7
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pecifying the A- axis Fig. 2.8 Specifying the A P axis All these examples are transcription factors See end of Chapter 2 (Wolpert) r a summary table of all the for a summary table of all the genes we will discuss. lever names: BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Clever names: http://tinman.nikunnakki.info/?q=by_organism
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aternal Maternal A-P genes ig 2 9 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) regions affected Fig. 2.9
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Maternal effect genes ( meg) eg. bicoid +/ meg X +/ meg 0% (+/ eg) 5% ( eg/meg 5% (+/+) 50% nd 50% (+/ meg) 25% ( meg/meg ) 25% (+/+) (Alive!) and Maternal Rescue Alive meg/meg X +/meg +/meg meg/meg ead) 50% and BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) (Dead) (Dead! strict maternal effect) Maternal effect lethality
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The anterior cytoplasm is necessary and sufficient for anterior structures bcd mutant no head two “tails” BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 2.10
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mRNA Protein BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 2.11
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nanos nanos bicoid caudal hunchback caudal nanos nanos represses hunchback translation
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BIOL 430 2010 lecture 11 handout - BIOL 430 Lecture 11...

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