BIOL 430 2010 lecture 12 handout

BIOL 430 2010 lecture 12 handout - BIOL 430 Lecture 12 Feb....

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
BIOL 430 Lecture 12 Feb. 5 th 2010 Development of the rosophila ody plan II Drosophila body plan II Zygotic D-V patterning ygotic A genes: GAP genes Zygotic A-P genes: GAP genes Segmentation: activation of the pair-rule genes BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
To Remind you from last lecture… aternal Genes for A : Maternal Genes for A-P: bicoid,hunchback nanos,caudal Maternal Genes for D-V: pipe, spatzle,toll, pelle,tube, cactus orsal BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) dorsal
Background image of page 2
What is the function of nanos? nanos nanos icoid caudal bicoid hunchback caudal nanos anos presses unchback anslation proteins 2 sets of gradients BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) nanos represses hunchback translation bicoid activates hunchback transcription bicoid represses caudal translation 4 proteins 2 sets of gradients
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Toll or Toll Like receptors are conserved and used in signaling the immune response. Toll is not a RTK. he first mutants in oll ere discovered in the genetic screens The first mutants in Toll were discovered in the genetic screens performed for lethal mutations that affected embryonic patterning. When Eric Wieschaus showed the cuticle pattern of one mutant to Christine Nüsslein-Volhard, and she exclaimed, “Toll!” (a German slang term to express emotion like “whoa”, crazy “mad” or ‘far- out’—nowadays kids say “phat” or “sweet” 2009– “sick”), and the gene became known by that name. Madhouse = Tollhaus flies a Toll like receptor is also shown to be involved in fighting In flies a Toll like receptor is also shown to be involved in fighting off bacterial infection BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) How can a +/m animal die if recessive?
Background image of page 4
Dorsal/Ventral Patterning: SUMMARY OF THE SYSTEM: cascade of ligands/receptors leading to the localized translocation of a transcription factor ( dorsal ) from cytoplasm to nucleus on the ventral side. pipe spatzle toll pelle/tube cactus dorsal GENETIC ANALYSIS : There are mutants with no dorsal structures ( cactus ) and mutants with no ventral structures ( toll and dorsal ) BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The DORSAL transcription factor can ct as a morphogen act as a morphogen.
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/06/2011 for the course BIOL 430 taught by Professor Dr.ianchin-sang during the Winter '10 term at Queens University.

Page1 / 26

BIOL 430 2010 lecture 12 handout - BIOL 430 Lecture 12 Feb....

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online