BIOL 430 2010 lecture 14 handout 6 slides

BIOL 430 2010 lecture 14 handout 6 slides - Lecture 14...

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1 Lecture 14 February 10 th 2010 Caenorhabditis elegans Development Cell-cell interaction in early development Asymmetry in C. elegans & Introduction to Dr. Chin-Sang’s Research BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) "You have made your way from worm to man, and much within you is still worm." Friedrich Nietzsche, Zarathustra's Prologue, 3 (1891) C. elegans is an Excellent Model Organism for Development Small size 1mm Fast life cycle 3days Hermaphrodite Amenable to genetics Sequenced genome BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Cell lineage determined Single cell resolution Many genetic tools and Markers available Link to movie Caenorhabditis elegans XX 959 somatic cells BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Figure 25.2 Klaus Kalthoff Analysis of Biological Development 2 nd ed. McGrawHill 100 μ m XO 1031 somatic cells Caenorhabditis elegans This worm is BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) C. elegans Movie from The Goldstein Lab: http://www.bio.unc.edu/faculty/goldstein/lab/movies.html crawling on its left side By studying C. elegans development we are learning crucial lessons about cancer, Alzheimers disease, muscular dystrophies, aging, and many other important aspects of human biology. 19,000 genes (100 MB) 6 chromosomes (5 autosomes and X chromosome) Hox genes TGF- β Wingless/Wnt Delta/Notch Ephrins/Eph RTK hedgehog like (no ortholog) and patched Some statistics: BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) zygotic transcription begins after 4 cell stage but maternal components control almost all of the development up to gastrulation at the 28 cell stage Recall: Xenopus MBT after 12 cell cycle divisions Sperm entry point defines the posterior end of the embryo. P granules
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This note was uploaded on 12/06/2011 for the course BIOL 430 taught by Professor Dr.ianchin-sang during the Winter '10 term at Queens University.

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BIOL 430 2010 lecture 14 handout 6 slides - Lecture 14...

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