BIOL 430 2010 lecture 14 handout

BIOL 430 2010 lecture 14 handout - Lecture 14 February 10...

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Unformatted text preview: Lecture 14 February 10 th 2010 Caenorhabditis elegans Development Cell-cell interaction in early development Asymmetry in C. elegans & Introduction Dr. Chin- angs esearch to Dr. Chin Sang s Research "You have made your way from worm to man, nd much within you is still worm " BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) and much within you is still worm." Friedrich Nietzsche, Zarathustra's Prologue, 3 (1891) C. elegans is an Excellent Model Organism for Development Small size 1mm Fast life cycle 3days Hermaphrodite Amenable to genetics Sequenced genome ell lineage determined Cell lineage determined Single cell resolution any genetic tools and Many genetic tools and Markers available BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Link to movie Caenorhabditis elegans X XX 59 somatic cells O 959 somatic cells XO 1031 somatic cells 100 m BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Figure 25.2 Klaus Kalthoff Analysis of Biological Development 2 nd ed. McGrawHill Caenorhabditis elegans This worm is crawling C. elegans Movie from The Goldstein Lab: http://www.bio.unc.edu/faculty/goldstein/lab/movies.html on its left side By studying C. elegans development we are learning crucial ssons about cancer lzheimers isease muscular dystrophies BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) lessons about cancer, Alzheimers disease, muscular dystrophies, aging, and many other important aspects of human biology. 19,000 genes (100 MB) Some statistics: 6 chromosomes (5 autosomes and X chromosome) Hox genes TGF- Wingless/Wnt Delta/Notch phrins/Eph RTK Ephrins/Eph RTK hedgehog like (no ortholog) and patched zygotic transcription begins after 4 cell stage but maternal components control almost all of the development up to gastrulation at the 28 cell stage ecall: enopus BT after 12 cell cycle divisions BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Recall: Xenopus MBT after 12 cell cycle divisions Sperm entry point defines the posterior end of the embryo....
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BIOL 430 2010 lecture 14 handout - Lecture 14 February 10...

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