BIOL 430 2010 lecture 15 handout 6 slides

BIOL 430 2010 lecture 15 handout 6 slides - The Vertebrate...

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1 BIOL 430 Lecture 15 February 12 th 2010 Caenorhabditis elegans BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Eph RTK Signaling continued Tyrosine 16 Eph Receptors EphA1 EphA2 EphA3 EphA5 EphA6 EphA7 EphA8 EphA4 EphA9 EphA10 9 Ephrins Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A5 Ephrin-A6 The Vertebrate Eph Receptors are the Largest Class of RTKs BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Kinase EphB1 EphB2 EphB3 EphB4 EphB6 EphB5 Ephrin-B2 Ephrin-B3 Ephrin-B1 Axon guidance Cell Migration Hind brain patterning Angiogenesis Cancer E rythropoietin- p roducing h epatocellular carcinoma cell line Roles in: BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 4.30 Eph Receptor Tyrosine Kinases And Cancer Research Frequently overexpressed in a wide variety of cancers e.g. . EphA2 is overexpressed in 40% of breast cancers EphA3 and EphB6 genes are often mutated in colorectal cancers Activated Eph RTKs can inhibit tumor formation. BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Activated Eph RTKs can inhibit ras MAP kinase pathway. Activated Eph RTKs can activate MAP kinase pathway Eph Signaling is a potential drug target for cancer intervention. There are significant gaps in our understanding on how these RTKs signal to exert specific functions. BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 10.30 Ephrins act as repulsive cues Ephrins and Eph Receptors Have Roles in Setting up Cell Boundaries BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Eph Ephrin Ephrin Eph Restricts Cell intermingling (formation of compartments in the hindbrain-rhombomeres) Expressed in a reciprocal pattern
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2 The hindbrain is divided into 8 rhombomeres (r1 to r8) r3 and r5 express Ephs BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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BIOL 430 2010 lecture 15 handout 6 slides - The Vertebrate...

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