BIOL 430 2010 lecture 15 handout

BIOL 430 2010 lecture 15 handout - BIOL 430 BIOL 430...

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IOL 430 BIOL 430 Lecture 15 February 12 th 2010 Caenorhabditis elegans Eph RTK Signaling continued BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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16 Eph Receptors phA1 9 Ephrins The Vertebrate Eph Receptors are the Largest Class of RTKs EphA1 EphA2 EphA3 EphA5 phA6 Ephrin-A1 Ephrin-A2 phrin 3 EphA6 EphA7 EphA8 EphA4 phA9 Ephrin-A3 Ephrin-A5 Ephrin-A6 Tyrosine Kinase EphA9 EphA10 EphB1 EphB2 Ephrin-B2 Ephrin-B3 EphB3 EphB4 EphB6 EphB5 Ephrin-B1 Axon guidance Cell Migration ind brain patterning Roles in: BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Hind brain patterning Angiogenesis Cancer E rythropoietin- p roducing h epatocellular carcinoma cell line
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ig 4 30 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 4.30
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Eph Receptor Tyrosine Kinases nd Cancer Research And Cancer Research Frequently overexpressed in a wide variety of cancers e.g. . EphA2 is overexpressed in 40% of breast cancers phA3 and EphB6 genes are often mutated in colorectal EphA3 and EphB6 genes are often mutated in colorectal cancers ctivated Eph RTKs can inhibit tumor formation Activated Eph RTKs can inhibit tumor formation. Activated Eph RTKs can inhibit ras MAP kinase pathway. Activated Eph RTKs can activate MAP kinase pathway Eph Signaling is a potential drug target for cancer intervention. There are significant gaps in our understanding on how BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) these RTKs signal to exert specific functions.
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phrins act as repulsive cues BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig. 10.30 Ephrins act as repulsive cues
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Ephrins and Eph Receptors Have Roles in Setting up Cell Boundaries Ep hE phrin Ephrin Eph p p p p xpressed in a reciprocal pattern Restricts Cell intermingling (formation of compartments in the Expressed in a reciprocal pattern BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) hindbrain-rhombomeres)
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The hindbrain is divided into 8 rhombomeres (r1 to r8)
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BIOL 430 2010 lecture 15 handout - BIOL 430 BIOL 430...

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