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Unformatted text preview: in recruiting SEPA-1 to the autophagosome. • PGL-1 and PGL-3: Components of PGL granules. • SEPA-1 (s uppressor of e ctopic P granule in a utophagy mutants): binds to LGG-1, required for PGL granule formation, found in somatic cells. Point form summary: BIOL430 Handout April 7 th , 2010 Mariam and Joanna 1) Autophagy degrades PGL granules in somatic cells. 2) PGL granules form in a gradual temporal fashion in somatic cells of autophagy mutants. 3) PGL granule components are maternally derived 4) sepa-1 is essential for PGL granule formation. 5) sepa-1 is essential for PGL component degradation by autophagy. 6) SEPA-1 is present in high levels during the 20-100 cell stage then decreases dramatically. 7) SEPA-1 is degraded by autophagy. 8) SEPA -1 and PGL components (PGL-1 and PGL-3) co-localize. 9) SEPA-1 and autophagy components (autophagosome) co-localize ....
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- Winter '10
- Lysosome, PGL