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Induced Pluripotent Stem Cells Handout

Induced Pluripotent Stem Cells Handout - Julia Gill and...

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Julia Gill and Kristen Kilroy March 9 th , 2010 Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and S. Yamanaka. (2007). Cell 131: 861-872. Key Terms: Embryonic Stem Cell: cell derived from the inner cell mass of a mammalian blastocyst that can be indefinitely maintained in a pluripotent state in culture (Wolpert et al. 2007; Takahashi et al. 2007). Pluripotent Cell: a cell that has the potential to differentiate into any cell type. iPS cells: induced pluripotent stem cells, are adult somatic cells that have been reprogrammed to a pluripotent state through the over-expression of four essential transcription factors: Sox2, Oct 3/4, Klf 4 and c-Myc. Yamanaka and Takahashi developed this method in 2006 using mice. Oct3/4: A transcription factor found in embryonic carcinoma cells, early embryos and germ lines that has a role in cell differentiation (Yamanaka 2007).
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