lecturenoteschap7-10-4slides - BCMB 3100 - Chapter 7...

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1 BCMB 3100 - Chapter 7 Introduction to Coenzymes & Vitamins (Partial notes. The bulk of this chapter will be learned through your group activity and through the web-based tutorial. SEE HANDOUTS!) Cofactors Et i l i Essential ions Coenzymes Cosubstrates Prosthetic groups Coenzymes structure/function/active group Coenzymes Some enzymes require cofactors for activity (1) ______________ (mostly metal ions) (2) ____________ (organic compounds) Apoenzyme + Cofactor Holoenzyme (protein only) (active) (inactive) Coenzymes • __________ act as group -transfer reagents • Hydrogen, electrons, or other groups can be transferred • Two types of coenzymes: metabolite coenzymes vitamin-derived coenzymes Fig 7.1 Types of cofactors * ATP Ca ++ K + Mg ++ Mn ++ Fe-S center zinc copper cobalt * SAM UDP-sugar * NAD + /NADP + * tetrahydrofolate * CoA * ubiquinone * protein coenzymes * FMN/FAD * TPP * PLP * Biotin * adenosyl/methyl- cobalamin * Lipoic acid/ lipoamide See Table 7.2 as useful summary table for coenzymes
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2 Coenzyme Classification • There are two classes of coenzymes (1) _____________ are altered
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This note was uploaded on 12/03/2011 for the course CHEM 3100 taught by Professor Dervartanian during the Fall '09 term at University of Georgia Athens.

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lecturenoteschap7-10-4slides - BCMB 3100 - Chapter 7...

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