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lecturenoteschap9-10-1slide - BCMB 3100 - Chapter 9 Lipids...

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BCMB 3100 - Chapter 9 Lipids Definition ajor classes Major classes Fatty acids Triacylglycerol lycerophospholipids Glycerophospholipids Sphingolipids Cholesterol
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___________ : water insoluble organic compounds in living organisms ipids are ydrophobic r mphipathic Lipids are hydrophobic or amphipathic In BCMB3100 we will emphasize *phospholipids *glycolipids *cholesterol (steroid) main lipids in most biological _________________ : main lipids in most biological membranes 2nd most abundant lipid in membranes _______________ : 2nd most abundant lipid in membranes (abundant in CNS) from animals and plants
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Fig 9.1 Structural relationships of major lipid classes
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Fig 9.2 Structure and nomenclature f tty acids of fatty acids
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Table 9.1 You must be able to draw the structure of those marked * * * * * * * common name IUPAC name 8:0 stearate ctadecanoate 18:0 stearate Octadecanoate 18:1 oleate cis- 9-Octadecenoate 18:2 linoleate cis,cis- 9,12-Octadecadienoate
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nsaturated A - Unsaturated FA at least one C-C double bond Saturated FA - no C-C double bonds Fig 9.3
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Fig 9.1 Structural relationships of major lipid classes
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Fig 9.5 Structure of a triacylglycerol ) Gl cerol (a) Glycerol backbone (b)Triacylglycerol (a) (b) ________________ are a neutral storage form g of fatty acids
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MEMBRANE LIPIDS : 3 major types = phospholipids, lycolipids & cholesterol glycolipids, & cholesterol _________________ : most abundant class of lipids in embranes (note: triacylglycerols most abundant on mass membranes (note: triacylglycerols most abundant on mass basis in mammals); derived from glycerol or sphingosine *lipids from glycerol = phosphoglycerides (also called glycerophospholipids ) t t id * phosphoglycerides consist f glycerol backbone, Fatty acid Fatty acid G L Y of glycerol backbone, two fatty acids & a hhl t d l h l C E R O Phosphate phosphorylated alcohol L alcohol
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atty acids in biological organisms atty acid ains (long aliphatic tails) in Fatty acids in biological organisms Fatty acid chains (long aliphatic tails) in phospholipids & glycolipids contain even # of carbons (12-20) with 16 and 18 being most common Fatty acids can be ____________ or ______________ Under physiological conditions fatty acids are ionized (pKa 4.5-5.0)
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Fig 9.1 Structural relationships of major lipid classes
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Fig 9.7 (a) Glycerol 3-P and (b) phosphatidate Be sure to see Table 9.2, page 260
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Fig 9.7
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Fig 9.8 Phospholipases hydrolyze phospholipids ___________ : enzymes at catalyze hydrolysis of that catalyze hydrolysis of triacylglycerols catalyze ______________ : catalyze hydrolysis of glycerophospholipids
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Fig 9.1 Structural relationships f major lipid classes of major lipid classes
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ig 9 10 Fig 9.10 (a) ____________ : structural backbone f sphingolipids of sphingolipids (b) ___________ : sphingosine + fatty acid at C2 Ceramide
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Fig. 9.10 (continued) (c) Sphingomyelin : present in plasma embrane & myelin membrane & myelin sheath around neurons
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Fig 9.11 Example of a Cerebroside: abundant in nerves Sugar -Sphingosine Fatty acid Structure of a alactocerebroside galactocerebroside
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Fig 9.12 Example of a Ganglioside Ganglioside G M2 (NeuNAc in blue) Cell surface, cell-cell interactions (e.g. blood group antigens) Hexosaminidase A cleaves here Mutation Tay-Sachs disease
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Fig 9.1 Structural relationships f major lipid classes of major lipid classes
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Fig 9.14
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This note was uploaded on 12/03/2011 for the course CHEM 3100 taught by Professor Dervartanian during the Fall '09 term at UGA.

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lecturenoteschap9-10-1slide - BCMB 3100 - Chapter 9 Lipids...

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