lecturenoteschap19-10-1slide

lecturenoteschap19-10-1slide - BCMB 3100 BCMB 3100 -...

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CMB 3100 ucleic Acids hapter 19 BCMB 3100 - Nucleic Acids - Chapter 19 iscovery of DNA Discovery of DNA Nucleotides, nucleosides & bases Polynucleotides DNA as genetic material Structure of double-stranded DNA hromatin Chromatin RNA 1 Nucleases
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NA is the genetic component of life DNA is the genetic component of life entral Dogma for Biological Information Flow DNA RNA PROTEIN Central Dogma for Biological Information Flow Friedrich Miescher (1869): discovered DNA (nuclein nucleic acid C, H, O, N, P 2
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DNA and RNA are made up of nucleotides ba s e + sugar + phosphate ) ______________ : base sugar phosphate (n) deoxyribonucleotide (sugar = 2-deoxyribose) ribonucleotide (sugar = ribose) ____________ : base + sugar f nucleotides: heterocyclic rings __________ of nucleotides: heterocyclic rings containing nitrogen wo class of bases: nd 3 Two class of bases: ____________ and ________
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Purines and Pyrimidines Figure 19.3 4
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Fig 19.4 Major pyrimidines and purines 5
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Fig 19.5 Tautomers of adenine and cytosine Amino versus Imino 6
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Fig 19.5 Tautomers of guanine, thymine and uracil t t i Lactam versus Lactim 7
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Ribose and Deoxyribose Figure 19.2  RNA DNA 8
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Nucleosides Figure 19.7 (a) Nucleoside structures 9
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Figure 19.7 (b) 10
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ig 19 8 Fig 19.8 Two conformations of nucleosides & nucleotides are ossible due to possible due to rotation around the lycosidic bond: glycosidic bond: syn and anti he The _________ conformation redominates 11 predominates
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Fig 19.1 Chemical structure of a ___________ 12
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13
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Fig 19.9 Structures of the deoxyribonucleoside-5’-monophosphates 14
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Fig 19.9 (continued) 15
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In vivo the negatively charged hosphates on nucleotides are phosphates on nucleotides are complexed with cations or positively arged proteins charged proteins *** 16
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CMB 3100 ucleic Acids hapter 19 BCMB 3100 - Nucleic Acids - Chapter 19 iscovery of DNA Discovery of DNA Nucleotides, nucleosides & bases Polynucleotides DNA as genetic material Structure of double-stranded DNA hromatin Chromatin RNA 17 Nucleases
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. ucleotides A. Nucleotides joined by 3’-5’ phosphodiester linkages Fig 19.11 Structure of the tetranucleotide 18 pdApdGpdTpdC
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tory of DNA as Genetic Material Story of DNA as Genetic Material Discovery of the structure of double stranded DNA, 1953 James Watson, Francis Crick, Rosalind Franklin, Maurice Wilkins 19
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Evidence that S = capsular polysaccharide DNA is the genetic = death R = no material in cells capsule = live Isolation & characterization f the of the transforming principle proved the chemical make-up of the genetic material 20
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Fig 19.6 Adjacent nucleotides can hydrogen bond to each other 24
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CMB 3100 ucleic Acids
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lecturenoteschap19-10-1slide - BCMB 3100 BCMB 3100 -...

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