lecturenoteschap19-10-2slides

lecturenoteschap19-10-2slides - BCMB 3100 - Nucleic Acids -...

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1 BCMB 3100 - Nucleic Acids - Chapter 19 Discovery of DNA Nucleotides, nucleosides & bases Polynucleotides DNA as genetic material Structure of double-stranded DNA 1 Chromatin RNA Nucleases DNA is the genetic component of life Central Dogma for Biological Information Flow DNA RNA PROTEIN Friedrich Miescher (1869): discovered DNA (nuclein 2 nucleic acid C, H, O, N, P
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2 DNA and RNA are made up of nucleotides ______________ : base + sugar + phosphate (n) deoxyribonucleotide (sugar = 2-deoxyribose) ribonucleotide (sugar = ribose) ____________ : base + sugar 3 __________ of nucleotides: heterocyclic rings containing nitrogen Two class of bases: ____________ and ________ Purines and Pyrimidines Figure 19 3 Figure 19.3 4
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3 Fig 19.4 Major pyrimidines and purines 5 Fig 19.5 Tautomers of adenine and cytosine Amino versus Imino 6
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4 Fig 19.5 Tautomers of guanine, thymine and uracil Lactam versus Lactim 7 Ribose and Deoxyribose Figure 19.2 8  RNA DNA
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5 Nucleosides Figure 19.7 (a) Nucleoside structures 9 Figure 19.7 (b) 10
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6 Fig 19.8 Two conformations of nucleosides & nucleotides are possible due to rotation around the glycosidic bond: syn and anti 11 The _________ conformation predominates Fig 19.1 Chemical structure of a ___________ 12
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7 13 Fig 19.9 Structures of the deoxyribonucleoside-5’-monophosphates 14
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8 Fig 19.9 (continued) 15 I i th ti l h d In vivo the negatively charged phosphates on nucleotides are complexed with cations or positively charged proteins 16 ***
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9 BCMB 3100 - Nucleic Acids - Chapter 19 Discovery of DNA Nucleotides, nucleosides & bases Polynucleotides DNA as genetic material Structure of double-stranded DNA 17 Chromatin RNA Nucleases A. Nucleotides joined by 3’-5’ phosphodiester linkages 18 Fig 19.11 Structure of the tetranucleotide pdApdGpdTpdC
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10 Story of DNA as Genetic Material Discovery of the structure of double stranded DNA, 1953 James Watson, Francis Crick, Rosalind Franklin, Maurice Wilkins 19 Evidence that DNA is the genetic ti l i S = capsular polysaccharide = death R = no capsule = material in cells live Isolation & characterization of the transforming principle proved 20 the chemical make-up of the genetic material
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11 21 22
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12 23 Fig 19.6 Adjacent Adjacent nucleotides can hydrogen bond to each other 24
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13 BCMB 3100 - Nucleic Acids - Chapter 19 Discovery of DNA
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lecturenoteschap19-10-2slides - BCMB 3100 - Nucleic Acids -...

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