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lecturenoteschap22-09-4slides

lecturenoteschap22-09-4slides - BCMB 3100 Chapter 22...

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1 BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA Ribosomes Initiation Elongation Termination How is the nucleotide code translated into a protein code? translation DNA  RNA  protein transcription 5’_____ UCA _____3’  NH 2 _____ Ser _____COO - ????? Adapter Molecule Hypothesis (Crick, 1958) mRNA  protein (codon) adapter molecule = tRNA Adapter molecule = ___________ (transfer RNA) (anticodon) ______________: relation between the sequence of bases in RNA (DNA) and the sequence of amino acids in protein. It is a three base code that is sequential, non- overlapping , and degenerate . BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA Ribosomes Initiation Elongation Termination
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2 Fig 22.1 Overlapping vs nonoverlapping reading of the three-letter code ***** NO!!!!! Fig 22.2 Three reading frames of mRNA • Translation of the correct message requires selection of the correct reading frame Fig 22.3 Standard genetic code * * * * BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA Ribosomes Initiation Elongation Termination
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