lecturenoteschap22-10-1slide

lecturenoteschap22-10-1slide - BCMB 3100 - Chapter 22...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA oc y N Ribosomes itiation Initiation Elongation Termination
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ow is the nucleotide code translated into a protein code? How is the nucleotide code translated into a protein code? translation DNA  RNA  protein transcription p CA 3’  H er COO 5’_____ UCA _____3’  NH 2 _____ Ser _____COO - ????? Adapter Molecule Hypothesis (Crick, 1958)
Background image of page 2
RNA  rotein mRNA  protein (codon) adapter molecule = tRNA Adapter molecule = ___________ (transfer RNA) (anticodon) ______________: relation between the sequence of bases in RNA (DNA) and the sequence of amino acids in protein. It is a three base code that is sequential, non- overlapping , and degenerate .
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
BCMB 3100 - Chapter 22 Translation translation Genetic code 3 letter code 1 st proposed y George Gamow tRNA Amino acyl tRNA by George Gamow 2 letter RNA code: 4 2 = 16 oc y N Ribosomes itiation 3 letter RNA code: 4 3 = 64 Initiation Elongation 4 letter RNA code: 4 4 = 254 Termination
Background image of page 4
Fig 22.1 Overlapping vs nonoverlapping ading of the ree tter code reading of the three-letter code NO!!!!! *****
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig 22.2 Three reading frames of mRNA • Translation of the correct message requires selection of the correct reading frame
Background image of page 6
Fig 22.3 Standard genetic code ** * *
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
CMB 3100 - hapt 22 BCMB 3100 Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA oc y N Ribosomes itiation Initiation Elongation Termination
Background image of page 8
Fig. 22.4 Place where • Cloverleaf structure of amino acid will be added tRNA tRNAs 73-95 Ψ = pseudouridylate D =dihydrouridylate nucleotides long. Anticodon base airs ith codon in pairs with codon in mRNA. ’ end always ends 3 end always ends in 3’ACC…….5’ mino acid is Amino acid is added to A at 3’ end
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig 22.5 Tertiary structure of tRNA ee also Fig 22 6) (see also Fig. 22.6)
Background image of page 10
BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA oc y N Ribosomes itiation Initiation Elongation Termination
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Aminoacyl-tRNA Synthetases • synthesize ________________ (specific amino cid covalently attached to 3’ end of specific tRNA acid covalently attached to 3 end of specific tRNA (named as: alanyl-tRNA Ala ) t least 20 different aminoacyl NA synthetases • At least 20 different aminoacyl-tRNA synthetases (1 per amino acid) • Each synthetase specific for a particular amino acid, but may recognize isoacceptor tRNAs • Synonymous codons may be recognized by isoacceptor tRNAs (different tRNAs that attach the same amino acid) (bacteria have 30-60 different tRNAs)
Background image of page 12
Aminoacyl-tRNA Synthetase Reaction
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/03/2011 for the course CHEM 3100 taught by Professor Dervartanian during the Fall '09 term at UGA.

Page1 / 52

lecturenoteschap22-10-1slide - BCMB 3100 - Chapter 22...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online