lecturenoteschap22-10-1slide

lecturenoteschap22-10-1slide - BCMB 3100 Chapter 22...

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BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA Ribosomes Initiation Elongation Termination
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How is the nucleotide code translated into a protein code? translation DNA  RNA  protein transcription 5’ UCA 3’  NH Ser COO - 5’_____ _____3’ 2 _____ _____COO ????? Adapter Molecule Hypothesis (Crick, 1958)
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mRNA  protein mRNA (codon) adapter molecule = tRNA Adapter molecule = ___________ (transfer RNA) (anticodon) ______________: relation between the sequence of bases i RNA (DNA) d th f i id i in RNA (DNA) and the sequence of amino acids in protein. It is a three base code that is sequential, non- overlapping , and degenerate .
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BCMB 3100 - Chapter 22 Translation translation Genetic code 3 letter code 1 st proposed by George Gamow tRNA Amino acyl tRNA 2 letter RNA code: 4 2 = 16 Ribosomes Initiation 3 letter RNA code: 4 3 = 64 Elongation 4 letter RNA code: 4 4 = 254 Termination
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Fig 22.1 Overlapping vs nonoverlapping reading of the three letter code reading of the three-letter code NO!!!!! *****
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Fig 22.2 Three reading frames of mRNA • Translation of the correct message requires selection of the correct reading frame
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Fig 22.3 Standard genetic code * * * *
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BCMB 3100 - Chapter 22 BCMB 3100 Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA Ribosomes Initiation Elongation Termination
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Fig. 22.4 Place where i id • Cloverleaf structure of amino acid will be added tRNA tRNAs 73-95 i Ψ = pseudouridylate D =dihydrouridylate nucleotides long. Anticodon base pairs ith codon in pairs with codon in mRNA. 3’ end always ends 3 end always ends in 3’ACC…….5’ Amino acid is Amino acid is added to A at 3’ end
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Fig 22.5 Tertiary structure of tRNA (see also Fig 22 6) (see also Fig. 22.6)
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BCMB 3100 - Chapter 22 Translation translation Genetic code tRNA Amino acyl tRNA Ribosomes Initiation Elongation Termination
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