2/4/2010 Thursday
For Two allele locus:
Let p= the frequency of one allele in the population (usually the dominant)
Let q= the frequency of the other allele
Notice that:
p + q = 1
P=1q
q=1p
Genotypes should occur in the population according to p^2 + 2pq + q^2 = 1
HardyWeinberg Equation
P^2 = proportion of the population that is homozygous for the first allele.
2pq= proportion of population that is heterozygous
Q^2 = proportion of population that is homozygous for the second allele.
should be able to find p or q given p or q.
If p=.6 what is q?
.4
What would be 2pq be if p=.6?
.5
HardyWeinberg Equilibrium
Is a null model….
Like Newton’s first law of motion Every object tends to remain in a state of uniform motion (or stasis)
assuming no external force is applied to it.
The HardyWeinberg equation will be satisfied as long as no evolution takes place
Population Genetics and Evolution
Evolution: change in gene frequencies in a population over time.
Due to differential reproduction among organisms bearing different alleles.
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 Spring '08
 GREGG
 Biology, Genetics, Evolution, Population Genetics

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