4. genomes - G e n es and Genomes I The huma n genome A how...

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Genes and Genomes I. The human genome A. how few genes it contains B. how big the genes are but how little is protein encoding C. how many genes have homologs in other organisms II. How different are we from one another? III. sequencing the human genome A. automated DNA sequencing B. shotgun cloning and computational alignment IV. How computer programs identify genes a. ORF’s b. comparative genomics
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Figure 4-10 Molecular Biology of the Cell (© Garland Science 2008) What have we learned from genome sequencing
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Comparing genomes: How many more genes does it take to make a human than a fly? 2008 estimate=20,500
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Average gene size in human genome is huge But in all organisms, average protein size= 300-500 aa’s 20,500
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