Cardiovascular-Frog-Lab 2 Blackboard 2011

Cardiovascular-Frog-Lab 2 Blackboard 2011 - Effects of...

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1 Effects of Autonomic Neurotransmitters and the Hormone Epinephrine on Cardiac Function Effects of Autonomic Cardiac Nerves and Epinephrine on Cardiac Function (Inotropic effect) (Inotropic effect) (Chronotropic effect) (Dromotropic effect) Norepinephrine and epinephrine acting upon b 1 -adrenergic receptors
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2 Control of Heart Rate (HR) SA nodal cells are pacemaker cells AV nodal cells are also pacemakers, but at a significantly lower rate ( 40-60 beats / min (bpm) Unregulated heart rate 100 bpm NE, E activation of b - adrenergic receptors in SA nodal cells increases heart rate ACh activation of muscarinic receptors in SA nodal cells decreases heart rate Fig. 12.13 Nodal cells lack voltage-gated Na + channels found in cardiac muscle cells Open while membrane is repolarizing and at negative values (HCN channel, non-specific cation channel) Pacemaker Potential SA Node Cell Upstroke of AP due to opening of voltage-gated Ca ++ (L) type channel P Na + , K + Repolarization due to opening of voltage-gated K + channels
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3 Control of Heart Rate (HR) SA nodal cells are pacemaker cells AV nodal cells are also pacemakers, but at a significantly lower rate ( 40-60
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Cardiovascular-Frog-Lab 2 Blackboard 2011 - Effects of...

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