NIA3 - Neurons in Action tutorials for week 3 You can work...

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Neurons in Action – tutorials for week 3 You can work on these tutorials at any time during the lab - e.g., while your group is waiting for a frog to dissect – or afterward. The NIA2 programs will also be installed on the computers in Life Sciences room 026. You may need a keycode to access this room – if it is not open, see your TA or Dr. Kernan. Axons – the Passive Axon This simulation models an axon that lacks voltage-activated channels and so cannot conduct an action potential. You can inject a stimulus current to see how the membrane potential changes at the site of injection and at other sites along the axon. Because the axon lacks voltage-gated channels, the stimulus is the only source of depolarizing current. As long as the stimulus persists, charge spreads passively along the axon, reaching a steady-state gradient which peaks at the injection site. The gradient discharges and flattens rapidly as soon as the stimulus ends. In this tutorial, try adjusting: - input stimulus current (Stimulus control – IClamp). - axon diameter (Axon Parameters). Increasing it will increase the membrane area (decreasing membrane resistance and increasing capacitance) and decrease the axial resistance.
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