Lecture 1 (317.11)

Lecture 1 (317.11) - BIO 317: Lecture 1 Prof. William...

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1 Prof. William Collins OfFce: 534 Life Sciences Building OfFce Hours: Mondays, 4:00 – 5:00 PM or by appointment Recommended Reading: Matthews, Chapter 1 BIO 317: Lecture 1 The Cell is the Basic Unit of Life • Why? • Need to Think in Terms of Compartments – Intracellular (IC±) vs. Extracellular (EC±) – Nucleus vs. Cytoplasm • Cell Signaling – Membrane delineated - fast (ms min) – Cytoplasm - slower and longer lasting (min hours) – Nuclear - slowest and longest lasting (hours days)
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2 Nerve Zinc Rod Touching Muscle Relaxed Frog Leg Muscle Copper Rod Touching Nerve Touch Rods Together Muscle Contracts Animal Electricity Luigi Galvani (1791) - First experiments on Animal Electricity Hypothesized that electricity is stored in muscle and that discharge of electricity from the muscle through the rods caused the muscle to contract. (creative explanation…… but WRONG!) Nerve Zinc Rod Touching Muscle Relaxed Frog Leg Muscle Copper Rod Touching Nerve Touch Rods Together Both Muscles Contract Carlo Matteucci (1840) - carried out definitive experiment. Demonstrated: • Electrical stimulation of nerve leads to muscle contraction • Excitable tissue produces electric current Nerve Touching Crushed Muscle
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3 ICF -70 mV ECF 0 mV Membrane Potential Membrane Potential - Every Cell Has an Electrical Potential The inside of a cell is more negative than the interstitial space around it. Excitable Cells - Some Cells Generate Rapid Changes in Membrane Potential called Action Potentials Neurons and Muscle Cells plasma membrane Measuring Biological Potentials Biological potentials can be easily measured using differential electronic amplifiers Source Electrical Potential Muscle Electromyogram (EMG) Heart Electrocardiogram (ECG) Brain Electroencephalogram (EEG) Nerve Electroneurogram (ENG)
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Lecture 1 (317.11) - BIO 317: Lecture 1 Prof. William...

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