Lecture 15 - Signaling Pathways 10/24/11 10 10/24/11 11 Ras...

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10/24/11 1 Signaling and Growth Control Normal Fibroblasts Transformed Fibroblasts
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10/24/11 2 Varmus Bishop Retrovirus
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10/24/11 3 Ray Erikson c-src protein structure Bart Sefton Tony Hunter
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10/24/11 4 Several ways to activate Src kinase Csk phosphorylates Y527 phosphatase removes P (Y527)
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10/24/11 5 Is cancer caused by mutation of a cellular gene that becomes dominant? Robert Weinberg
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10/24/11 6 cloning of the Frst human oncogene
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10/24/11 7 Carcinogen = Mutagen? control + mutagen Polycyclic Aromatic Hydrocarbons
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10/24/11 8 smokers non-smokers Bruce Ames rules!
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10/24/11 9 GDP Inactive GTP Active GTP GDP P i Intrinsic GTP hydrolysis Enhanced by exchange factors Enhanced by GTPase activating protein
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Unformatted text preview: Signaling Pathways 10/24/11 10 10/24/11 11 Ras activation cycle Ras activating mutation inhibitory mutation X X Are src and ras connected in a common cell growth control pathway? Src* X anti-Ras Ras* anti-Src no block 10/24/11 12 Tyrosine kinase (src) ? Ras Stanley Cohen EGF 10/24/11 13 GEF /GEF 10/24/11 14 GEF EGF EGFR Note: Sos = GEF Erk = MAPK proto-oncoprotein pathway GEF 10/24/11 15 (MAP kinase family) At the plasma membrane, Src can amplify and transduce signals from receptors to convey signals to the nucleus, cytoskeleton and other cellular components to control, for example, cell growth and proliferation...
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This note was uploaded on 12/06/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Spring '08 term at SUNY Stony Brook.

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Lecture 15 - Signaling Pathways 10/24/11 10 10/24/11 11 Ras...

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