Lecture 16 - 10/26/11 Are src and ras connected in a common...

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10/26/11 1 Are src and ras connected in a common cell growth control pathway? Src* X anti-Ras Ras* anti-Src no block Tyrosine kinase (src) ? Ras protein kinase protein kinase protein kinase
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10/26/11 2 Stanley Cohen EGF GEF GEF
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10/26/11 3 /GEF GEF
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10/26/11 4 EGF EGFR Note: Sos = GEF Erk = MAPK proto-oncoprotein pathway GEF (MAP kinase family)
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10/26/11 5 At the plasma membrane, Src can amplify and transduce signals from receptors to convey signals to the nucleus, cytoskeleton and other cellular components to control, for example, cell growth and proliferation. Neuronal Growth Factors / Neurotrophins
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10/26/11 6 Rita Levi-Montalcini shared Nobel prize with Stanley Cohen for her discovery of Nerve Growth Factor Levi-Montalcini and chick embryos Elmer Bueker and the sarcoma Dorsal root ganglia (DRG)
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10/26/11 7 - NGF + NGF The Assay NGF acts directly Purifcation o± the ±actor A rich source o± ±actor, helps…
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10/26/11 8 Proof of NGF action Does NGF stimulate proliferation? Victor Hamburger and the
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Lecture 16 - 10/26/11 Are src and ras connected in a common...

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