lecture 17 - 10/31/11 Mechanism of NGF Action Primary...

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Unformatted text preview: 10/31/11 Mechanism of NGF Action Primary Neuron Culture 1 10/31/11 Does NGF influence neuronal phenotype, or is phenotype intrinsic to the neuron? 2 10/31/11 PC12 cells - NGF + NGF Proteins 3 10/31/11 Neuronal Growth Factor Actions Proof of NGF Actions In Vivo 4 10/31/11 What is the signaling pathway for NGF? NGF uses a proto-oncoprotein pathway for neuronal survival and development 5 10/31/11 -NGF +NGF or injection of Ras oncoprotein (mimic) NGF action requires Ras ras 6 10/31/11 What is the receptor for NGF? Trk oncogene (tropomyosin receptor kinase) 7 10/31/11 The Trk orphan receptor is expressed in neurons TrkA 8 10/31/11 Why does an oncogene pathway mediate different effects in neurons? How does the NGF signaling pathway mediate a wide range of effects? In Vivo Proteins How do we know that Neurotrophins mediate effects other than survival? 9 10/31/11 Receptor/Adaptor --> Ras --> Raf --> Mek --> Erk/MapK GEF GEF 10 10/31/11 SHC uses SH2 and PTB domains FRS2 uses a PTB domain (Phospho-Tyrosine Binding domain) 11 10/31/11 PIP3 PDK1/2 targets PKB targets NGF/TrkA 12 10/31/11 ? PIP3 PDK1/2 targets PKB targets 13 10/31/11 PKB 14 ...
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This note was uploaded on 12/06/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Spring '08 term at SUNY Stony Brook.

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lecture 17 - 10/31/11 Mechanism of NGF Action Primary...

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