Accvatedsmadcomplexestranslocateintothenucleuswherethe

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Unformatted text preview: equently
acCvated
type
I
 receptors
phosphorylate
selected
Smads
at
C‐terminal
serines,
and
these
receptor‐acCvated
Smads
(R‐Smads)
then
form
a
complex
with
a
 common
Smad4.
AcCvated
Smad
complexes
translocate
into
the
nucleus,
where
they
regulate
transcripCon
of
target
genes,
through
physical
 interacCon
and
funcConal
cooperaCon
with
DNA‐binding
transcripCon
factors
(X)
and
CBP
or
p300
coacCvators.
AcCvaCon
of
R‐Smads
by
 type
I
receptor
kinases
is
inhibited
by
Smad6
or
Smad7.
R‐Smads
and
Smad4
shuTle
between
nucleus
and
cytoplasm.
 Signaling
and
Gene
Expression
 3 11/28/11 The steps of eukaryotic post-transcriptional processing Decay
/
storage
 P‐bodies
/
Stress
Granules
 Trans...
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This note was uploaded on 12/06/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Spring '08 term at SUNY Stony Brook.

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