Lecture 24 - MAPK rsk 1 Figure 15-60 Molecular Biology of the Cell Garland Science 2008 2 3 CBP Increase of Gene Expression 1 Histone

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11/30/11 1 MAPK rsk
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11/30/11 2 Figure 15-60 Molecular Biology of the Cell (© Garland Science 2008)
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11/30/11 3
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11/30/11 4 CBP - Increase of Gene Expression 1.Histone acetyltransferase – Acetylates lysine residues 2. Bind factors involved in cell growth and diFeren7a7on 3. Recruitment of basal transcrip7on machinery (RNA Pol‐II) Nuclear Hormone Receptors Pathologies e.g. Diabetes, Cancer, Osteoporosis, etc. Ligand-Inducible Transcription Factors Involved in Growth, Differentiation & Homeostasis
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11/30/11 5 Nuclear Signaling Molecules “Stress Hormone” “Anabolic Steroid” “Pregnancy Hormone” “Regulator of Metabolism” Ca 2+ & P Homeostasis “Growth, development, differentiation”
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11/30/11 6 Estrogens • Pregnancy • Pool for Estradiol • Secondary sex characteristics • Prepares reproductive tissues • Sertoli cells in seminiferous tubules (male) Prevention of germ cell apoptosis? Estriol By placenta during pregnancy RU-486/Mifepristone
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This note was uploaded on 12/06/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Spring '08 term at SUNY Stony Brook.

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Lecture 24 - MAPK rsk 1 Figure 15-60 Molecular Biology of the Cell Garland Science 2008 2 3 CBP Increase of Gene Expression 1 Histone

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