Lecture 25(1) - How Do Nuclear Receptors Activate...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
12/6/11 1 How Do Nuclear Receptors Activate Transcription? Chromatin Structure
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
12/6/11 2 Nucleosome Assembly Defining the Nucleosome
Background image of page 2
12/6/11 3 Transcription Activation Complex P300 & CBP - Increase of Gene Expression 1. Histone acetyltransferase – Acetylates lysine residues 2. Bind factors involved in cell growth and differentiation 3. Recruitment of basal transcription machinery (RNA Pol-II)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
12/6/11 4 Activation Model Activation Model Protein arginine N-methyltransferase 1 Arg-3 of H4
Background image of page 4
12/6/11 5 co-activators are common to multiple pathways Histone Modification – Highly Dynamic Available When Needed
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
12/6/11 6 Acetylation/Deacetylation The Histone Code
Background image of page 6
12/6/11 7 Sequence of Transcriptional Controls Recruitment of coactivators or corepressors mediates transcriptional activation or repression HDAC
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
12/6/11 8 Nuclear receptors (NRs), such as vitamin D receptor (VDR), are transcription factors that regulate gene activity in a ligand dependent manner. This regulation is transmitted via specific DNA regions, hormone response
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 9

Lecture 25(1) - How Do Nuclear Receptors Activate...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online