MelanomaSymptoms

MelanomaSymptoms - women o The malignant cells invade...

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Melanoma Symptoms Malignant melanoma is caused by an abnormal proliferation of melanocytes. Small clusters of melanocytes are known as moles or naevi and typically present in childhood and adolescence. Malignant melanoma may develop in an existing mole or in normal skin. Early signs of melanoma are summarized by the mnemonic "ABCDE":- Asymmetry Borders (irregular) Colour (variegated) Diameter (greater than 6 mm (0.24 in), about the size of a pencil eraser) Evolving over time/Everything else At later stages, the mole may itch, ulcerate or bleed. Less commonly melanomas may also appear in the eye, either in the iris or the choroid lining. Melanomas may also appear under the nail bed, in the nose or in the superficial lining of internal organs such as the oesophagus. Symptoms will be related to the tissue in which the melanoma is found. There are four main types of melanoma and can be categorised as:- Superficial spreading o Accounts for 70% of cases and typically occur on the back of the next in men and legs in
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Unformatted text preview: women o The malignant cells invade deeper tissues but typically spread out horizontally first Nodular o Often appear as a nodule on the skin which bleed o More commonly found on the chest and back o This form of melanoma spreads only into the deep tissues and the risk of spread to distant organs is high Acral o These appear on the palms of the hands and soles of the feet; often near the nail beds where there may be discolouration Lentigo maligna o Typically present as dark brown flat sub-cuticular patches of the faces of sun-damaged elderly people o They may spread after years of dormancy Causes Malignant melanoma is usually caused by UV exposure, either from direct sun exposure or Sun-beds. Due to the dark pigmentation of melanocytes they absorb more UV light and as such their DNA can become damaged. Other risk factors include:- Fair skin light skinned people are at the highest risk of melanoma Sunburn sustained in childhood High number of moles...
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MelanomaSymptoms - women o The malignant cells invade...

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