General anaesthesia Muscle relaxants

General anaesthesia Muscle relaxants - General anaesthesia...

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General anaesthesia Muscle relaxants Depolarising (e.g. suxamethonium) Non-depolarising (e.g. atracuronium) Mimics action of acetylcholine causing membrane depolarisation. Depolarises muscle cell membrane Not metabolized by acetycholinesterase Prevents further muscle activity Lasts for several minutes before metabolisation by plasma pseudocholinesterase*. Compete with acetylcholine for access to receptors but do no cause depolarisation. Used for: Maintaining relaxation following suxamethonium Facilitating non-urgent tracheal intubation * A genetic fault in the pseudocholinesterase gene may prolong this period. Heterozygotes have some pseudocholinesterase and the relaxation effect in merely increased to 15-20 minutes. Homozygotes have no fully effective psedocholinesterase and will be apnoeic for 3-4 hours during which time they must be managed appropriately! Drug Dose Modality Notes Suxamethonium 1.5 mg/kg IV, IM, SC Depolarising Rapid onset – muscle
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