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Cushing2 - Cushing's syndrome Cushing's syndrome is a...

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Cushing's syndrome Cushing's syndrome is a hormone disorder caused by high levels of cortisol, a glucocorticoid, in the blood. This can be caused by taking glucocorticoid drugs, or by tumours that produce cortisol or adrenocorticotropic hormone (ACTH) or Corticotrophin Releasing Hormone (CRH). Symptoms Glucocorticoids are hormones essential for the processing of carbohydrates, fats and proteins. If cortisol is present in excessive amounts, it has many harmful effects including:- Rapid weight gain with a central (abdominal) distribution o Wight gain around the face is termed a “moon face” o Some patients may develop a “buffalo hump” Muscle wasting occurs in the muscles of the legs and arms The skin becomes characteristically thin and easily bruised o Due to increase fat deposition the skin and thinned skin stretch marks called striae appear on the abdomen, breasts and shoulders In women there is an increased tendency to develop acne, become hirsute and loos hair in a
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