Cushing - Prognosis Left untreated, Cushings syndrome,...

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Cushing's syndrome Treatment The clinical treatment of Cushing’s syndrome is largely dependent on the cause. Cushing’s disease is primarily treated using surgery to remove the tumour within the pituitary gland. If the entire pituitary gland is removed, lifelong replacement hormones will be needed to replace what is lost. Surgery can also be used to remove adrenal tumours and ectopic ACTH secreting tumours, however prior to surgery the drug metyrapone may be used to reduce blood cortisol levels. In iatrogenic Cushing’s causative drugs may be titrated down and replaced by Non-steroidal anti inflammatory agents such as methotrexate and azathioprine.
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Unformatted text preview: Prognosis Left untreated, Cushings syndrome, leads to increasingly severe symptoms and cause disease such as diabetes, cardiovascular disease, liver and kidney failure, hyperthyroidism as well as chronic infections. Cushings syndrome can be treated effectively and usually, if caught early, has a good prognosis. Cushings disease has a poorer prognosis; impaired pituitary function may result if the condition is not recognised. Prevention Cushings syndrome in its iatrogenic form can be prevented by using corticosteroids cautiously at levels which suppress inflammatory diseases without causing side effects....
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