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Unformatted text preview: water reabsorption and increased secretion) Central DI results from a deficiency of ADH, usually due to the decrease in its release from the posterior pituitary gland. This could be due to pituitary surgery or a craniopharyngioma. Other causes include, Post-traumatic head injury, intracranial infection, congenital malformation or pituitary stalk lesions. Peripheral DI (or nephrogenic DI) results from a renal insensitivity or resistance to ADH. This is most often due to long-term or chronic treatments with nephrogenic drugs, such as Lithium. Other drugs may include rifampin, colchicine, cisplatin and gentamicin, There is also a correlation with DI and pregnancy Epidemiology There is no clear epidemiological correlation between age, race and demographic groups....
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- Fall '10