Phaeochromocytoma - Phaeochromocytoma Phaeochromocytoma is...

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Phaeochromocytoma Phaeochromocytoma is a catecholamine producing tumour of chromaffin cells usually within adrenal medulla Symptoms Classical triad o episodic headache o sweating o tachycardia(BP may be elevated or reduced) o Heart – tachycardia, palpitations/VT, shortness of breath, angina o CNS – headache, visual disturbance, tremor, dizziness o Psych – anxiety, panic,confusion o Gastrointestinal tract – diarrhoea and vomiting, abdominal pain Causes Up to 25% of pheochromocytomas may be familial. Mutations of the genes VHL, RET, NF1(Gene 17 Neurofibromatosis type 1), SDHB and SDHD are all known to cause familial pheochromocytoma/extra- adrenal paraganglioma. Pheochromocytoma is a tumour of the multiple endocrine neoplasia syndrome, type IIA and type IIB (also known as MEN IIA and MEN IIB, respectively). The other component neoplasms of that syndrome include parathyroid adenomas, and medullary thyroid cancer. Mutations in the autosomal RET proto-oncogene drives these malignancies . Common mutations in the RET oncogene may also account for medullary
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This note was uploaded on 12/04/2011 for the course ANT ANT2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Phaeochromocytoma - Phaeochromocytoma Phaeochromocytoma is...

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