Phaeochromocytoma Treatment

Phaeochromocytoma Treatment - Phaeochromocytoma Treatment...

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Unformatted text preview: Phaeochromocytoma Treatment Surgical resection of the tumour is the treatment of first choice, either by open laparotomy or else laparoscopy. Given the complexity of perioperative management, and the potential for catastrophic intra and postoperative complications, such surgery should be performed only at centres experienced in the management of this disorder. In addition to the surgical expertise that such centres can provide, they will also have the necessary endocrine and anesthesia resources. It may also be necessary to carry out adrenalectomy, a complete surgical removal of the affected adrenal gland(s). Either surgical option requires prior treatment with the non-specific and irreversible alpha adrenoceptor blocker Phenoxybenzamine (Irreversible blockade is important because a massive release of catecholamines from the tumor may overcome a reversible blockade). Doing so permits the surgery to proceed while minimizing the likelihood of severe intraoperative hypertension (as might occur when the...
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