Toxic multinodular goitre

Toxic multinodular goitre - Toxic multinodular goitre .back...

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Toxic multinodular goitre «...back Toxic multinodular goitre (also known as Plummer’s Disease) is a sub-type of hyperthyroidism that results from multiple autonomously functioning nodules that secretes an excessive amount of thyroid hormones. Symptoms The signs and symptoms exhibited by patients with toxic multinodular goitre are similar to that of hyperthyroidism: Neck lump (goitre) Heat Intolerance with moist Skin Hyperphagia with weight loss Diarrhoea Lid lag (exophthalmos [Grave’s] is absent) Tachycardia Causes The cause of toxic multinodular goitre globally is usually due to iodine deficiency, although in developed countries this is usually seen in patients with a long-standing goitre. The pathophysiology is often due to TSH receptor mutation and over production of thyroid hormones. The important risk factors for toxic multinodular goitre include: iodine deficiency, age >40 y/o and/or head/ neck radiation exposure Epidemiology
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Worldwide, iodine deficiency is the most common cause of toxic nodular goitres. These represent
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Toxic multinodular goitre - Toxic multinodular goitre .back...

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