Nasopharyngeal Carcinom1

Nasopharyngeal Carcinom1 - sinusitis may occur leading to...

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Nasopharyngeal Carcinoma Nasopharyngeal Carcinoma (NPC) is the most common cancer originating in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract. Symptoms The nasopharynx is the area between the nasal cavity and the back of the throat. In the UK tumours in this are uncommon. Over 50% of patients with a nasopharyngeal tumour have no symptoms and only become aware of the problem when they visit their GP’s with an enlarged lymph node. As the tumour increases in size and exerts a pressure effect on adjacent tissues, the following symptoms may develop:- Epistaxis (nose bleeds) Unilateral nasal obstruction which may make breathing difficult Unilateral deafness Pain or tinnitus in the ears Dysphagia (due to involvement and paralysis of the cranial nerves) If the nasopharyngeal obstruction becomes larger or if there is a secondary infection in the sinuses,
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Unformatted text preview: sinusitis may occur, leading to pus laden nasal discharge and severe headaches. Tumours which obstruct the Eustachian tubes may cause an initially sterile otitis media which can then become colonised and infected. Causes The causes of NPC are unclear. Perhaps surprisingly, tobacco smoking isn’t strongly associated with NPC. The aetiology of NPC seems to follow a multi-step process, in which the Epstein-Barr Virus (EBV), ethnic background, and environmental carcinogens all seem to play an important role. It has been shown that EBV DNA was detectable in the plasma samples of 96% of patients with non-keratinizing NPC, compared with only 7% in controls. In adults, other likely etiological factors include genetic susceptibility, consumption of food (in particular salted fish) containing carcinogenic volatile nitrosamines....
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Nasopharyngeal Carcinom1 - sinusitis may occur leading to...

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