Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma - may indicate metastatic spread...

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Nasopharyngeal Carcinoma Epidemiology NPC is uncommon in the UK and most other Western Nations, but is extremely common in southern regions of China, particularly in Guangdong where it accounts for 18% of all cancers. In China it has an incidence of around 25 cases per 100,000 people, 25 times higher than the rest of the world. It is also quite common in Taiwan. This could be due to the South East Asian diet which typically includes consumption of salted fish and meat. While NPC is seen primarily in middle-aged persons in Asia, a high proportion of African cases appear in children. Diagnosis Most people with obvious symptoms are referred to an ENT specialist who will perform an extensive examination of the patient’s nasopharyngeal region. A naso-endoscope may be used to help visualise the nasopharynx. Another vital part of the examination includes feeling for enlarged local lymph nodes which
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Unformatted text preview: may indicate metastatic spread. If enlarged lymph nodes are felt they will need to be biopsied to confirm or rule out spread. Once NPC is diagnosed it needs to be staged to assess how far the malignancy has spread and help guide treatment. Staging is aided with either CT or MRI scans which can visualise the size, location and spread of disease. Four stages of NPC are recognised:-• Stage 1 o NPC is very localised to the nasopharynx • Stage 2 o The NPC has not spread outside the nasopharynx and doesn’t involve spread to the lymph nodes but it has spread into the surrounding tissue • Stage 3 o The NPC has spread outside of the nasopharynx to the lymph nodes on the same side as the tumour • Stage 4 o The NPC has spread to other tissues such as the bones or nerves of the head. Distant spread to other lymph nodes may have occurred...
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Nasopharyngeal Carcinoma - may indicate metastatic spread...

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