Cirrhosi1 - Cirrhosis Cirrhosis is a consequence of chronic...

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Cirrhosis Cirrhosis is a consequence of chronic liver disease characterised by replacement of liver tissue by fibrosis, scar tissue and regenerative nodules leading to loss of liver function. When the liver becomes cirrhosed portal blood flow is restricted leading to portal hypertension. Symptoms The clinical features of cirrhosis are largely the result of portal hypertension and liver cell failure. Portal hypertension causes:- Enlargement of the spleen Dilatation of the veins in the o Oesphagus (oesophageal Varices) o Umbilical veins (Caput medusa) o Haemorrhoids Fluid to collect in the peritoneal cavity (Ascities) Failure of liver cell function causes:- Hepatic jaundice and pruritis Abnormal bruising due to clotting disturbance Altered metabolism of oestrogen leading to high estrodiol levels and:- o Spider Naevi o Palmer erythema o Gynaecomastia o Hypogonadism Hepatic encephalopathy and Asterixis (due to the accumulation of nitrogenous waste products) Other signs include an enlarged or shrunken liver, a Cruveilhier-Baumgarten murmur and clubbing or Hypertrophic Osteoarthropathy.
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This note was uploaded on 12/04/2011 for the course ANT ANT2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Cirrhosi1 - Cirrhosis Cirrhosis is a consequence of chronic...

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