Cirrhosis - Cirrhosis Epidemiology Cirrhosis can occur in...

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Cirrhosis Epidemiology Cirrhosis can occur in all age groups but it is predominantly found in people over the age of 30. Cirrhosis and chronic liver disease were the 10th leading cause of death for men and the 12th for women in the UK in 2001. Established cirrhosis has a 10-year mortality of 34-66%, largely dependent on the cause of the cirrhosis; alcoholic cirrhosis has a worse prognosis than primary biliary cirrhosis and cirrhosis due to hepatitis. Diagnosis A diagnosis of cirrhosis can be confirmed by the following investigations:- Blood tests o FBC - anaemia (due to bleeding) and increased size of RBC o LFTs Bilirubin may be normal or elevated AST, ALT, ALP and gammaGT all elevated Albumin decreased o Clotting screen – PT/INR increased o o Autoantibodies – ANA, AMA and SMA Liver ultrasound and duplex o May show either hepatomegaly or a small nodular liver o May also show hepatic vein thrombosis MRI – Allows visualisation of the liver
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Cirrhosis - Cirrhosis Epidemiology Cirrhosis can occur in...

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