Milestones in Molecular GeneticsAvery, MacLeod and McCarty (1944, in Experimental Medicine, vol. 79). Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Beginning with Griffeth’s studies of transformation of rough Pneumococcus into smooth, Avery, MacLeod and McCarty demonstrated that the transforming principle was DNA, not protein.Hershey and Chase (1952, in Journal of General Physiology, vol 36(1)). Independent functions of viral protein and nucleic acids in growth of bacteriophage. Using bacterial viruses, Hershey and Chase demonstrated that the infectious portion of a virus is its DNA, not its protein.Chargaff (1950, in Experimentia, vol. 6). Chemical structural specificity of nucleic acids and mechanism of their enzymatic degredation. Chargaff showed that all DNA molecules contained equal numbers of adenine and thymine bearing
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