Study Guide II - Study Guide for Exam 2 Study Guide Exam...

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Study Guide for Exam 2 Page 1 Study Guide- Exam 2 (covers Classes 2.1 through 2.6) Class 2.1---02/08/07: The Genetic Code Know the following terms: Codon, anticodon, synonym, third-base degeneracy, wobble hypothesis, proofreading (relative to synthethase charging), suppressor tRNAs, free ribosomes, membrane-bound ribosomes, post- translational translocation, co-translational translocation, signal sequence, signal recognition particle (SRP), SRP receptor, 11S ribonucleoprotein complex, 7S RNA, translocon. Understand the Following Concepts: 1. Be able to use the codon dictionary to translate a strand of mRNA. 2. Be able to pick out the wobble base in a codon and an anticodon. 3. Be able to recognize some of the more common modified bases found in tRNAs. 4. Know which bases Inosine, queuosine, and 2-thiouridine can base pair with. 5. Understand the relationship between the number of codons, tRNAs, and aminoacyl-tRNA synthethases. 6. Understand the mechanism of how aminoacyl-tRNA synthetases are charged. 7. Understand how a suppressor tRNA works to suppress a missense or nonsense mutation. 8. Know where and how protein synthesis takes place in different locations within cells. 9. Know the difference and understand the mechanisms for post-translational translocation and co-translational translocation of proteins. 10. Understand the structure and role of the signal sequence in synthesizing proteins that are membrane bound or secreted. 11. Know the structure of the SRP and the SRP receptor. 12. Understand the role of GTP in co-translational translocation. 13. Know the structure of the translocon. 14. Understand the general mechanisms by which proteins are imported into mitochondria and chloroplasts. Class 2.2---02/15/07: Transcription Terms: Promoter, startpoint, terminator, transcription unit, pre-mRNA, upstream sequence, downstream sequence, transcription bubble, closed promoter complex, open promoter complex, bridge, , holoenzyme, core enzyme, sigma factos, tight binding, abortive initiation, promoter clearance, up promoter mutations, down promoter mutations, gyrase, topoisomerase I, antitermination, intrinsic terminators, rho-dependent terminators, rut sites. Concepts: 1. Be able to predict the sequence and orientation of an RNA transcribed from a labeled double-stranded DNA molecule.
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Study Guide for Exam 2 Page 2 2. Know what happens during each of the major stages of transcription. 3. Understand the difference an open and closed promoter complex. 4. Know the basic structure of the RNA polymerase complex and how the structure determines its different functions during transcription. 5. Be familiar with the holoenzyme structure of RNA polymerase and the concept of sigma factors. 6. Know how the binding of sigma factors affects the affinity of the RNA polymerase for
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Study Guide II - Study Guide for Exam 2 Study Guide Exam...

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