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Section 6 slides - Immune System Response Overview/Review...

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10/31/11 1 Immune System Response Overview/Review BARRIER PRIMARY DEFENSE SKIN, INTACT MUCOSA, GENERAL MOLECULAR MECHANISMS CELLULAR – phagocytic cells, lymphocytes SECONDARY DEFENSE INNATE IMMUNE SYSTEM NON-SPECIFIC, phagocytic cells THIRD DEFENSE – lymphocytes ACQUIRED IMMUNE SYSTEM SPECIFIC Innate Immunity Anatomical Barriers Skin mechanical barrier Mucous membrane mucus traps foreign organisms Innate Immunity Physiological Barriers (Inhibit foreign organisms) Body temperature pH (gastric acidity) Oxygen tension Oxidative bursts creating oxygen radicals Soluble factors Lysozyme Complement Interferon Cytokines Innate Immunity Soluble Factors Lysozyme destroys bacterial cell walls and some viruses; (in tears) SLPI isolated in saliva Secretory Leukocyte Protease Inhibitor binds WBC - blocks HIV infection also in breast milk, genital secretions Innate Immunity Soluble Factors Complement damages pathogen s membrane Interferon decreases infection of uninfected cells Cytokines from Mø influence immune system function Two Types of Cellular Immunity INNATE Basic prevention Defense against most things foreign First responder ACQUIRED Specific Responds to some, but not all things that are foreign Delayed but increasing response Memory
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10/31/11 2 Terms Cytokines - growth factors secreted by cells that mediate a biological effect Lymphokines - cytokines secreted by lymphocytes, monocytes and Mø Chemokines - cytokines that play a role in inflammatory response Attract phagocytic cells CCR5 and CXCR4 are immune system chemokine receptors Remember they serve as co-receptors for HIV Specific Immunity Specificity recognizes differences in antigens Diversity recognizes zillions of different epitopes Memory remembers and responds to subsequent attacks Self-Non-self recognition does not attack self Lymphocytes Produced in bone marrow Circulate in blood and lymphatic system (primary location) Mediate specific immunity Recognize/respond to foreign antigens 2 Types of Lymphocytes B Lymphocytes Humoral Immunity - produce antibody T Lymphocytes
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