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Unformatted text preview: Lecture Summary 27 October 30, 2006 Chapter 10 - Alkyl Halides Preparation of Alkyl Halides - substitution of alcohols The conditions for substitution of an alcohol functional group with a halogen depends on the degree of alkyl substitution on the alchol. Alcohol Chloride Bromide tertiary (3°) HCl HBr primary (1°) or secondary (2°) SOCl 2 PBr 3 Preparation of Organometallic Compounds - Grignard reagents Alkyl halides are good electrophiles. We will examine their reactivity in nucleophilic substitution in detail in the next chapter. Another useful property of alkyl halides as that reducing metals can insert between the C-X bond to prepare a C-metal bond. This drastically alters the reactivity as the metal is less electronegative than carbon. Thus, the reactivity of the carbon is reversed from being an electrophile to being a nucleophile. Grignard reagents are formed from the insertion of Mg metal into the C-X bond. These reagents are very reactive as bases and electrophiles and are extremely sensitive to any source of proton...
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This note was uploaded on 12/06/2011 for the course CHEM 341 taught by Professor Sun during the Fall '08 term at ND State.
- Fall '08