SyntheticStrategy

SyntheticStrategy - Organic Synthesis Strategy Organic...

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Unformatted text preview: Organic Synthesis Strategy Organic Synthesis 2 The preparation of more complex molecules from commercially available starting materials via a multistep sequence of transformations . Starting Materials Target Product O HO Ac O OH Ac O H Ph O C O O O PhC O HN OH O Ideal Organic Synthesis 3 Highest chemical yields (and purity) - important over many steps. As concise as possible. Convergent is more efFcient. Introduce as many bonds and as much complexity as possible in a single operation. Affect of Yield on Overall EfFciency 4 Number of Steps OVERALL Yield average yield per step 80% 90% 5 32% 53% 10 10% 31% 20 1.1% 11% 30 10-3 % 4% 60% 8% 0.6% 0.004% 10-7 % Affect of Convergency on Overall EfFciency 5 Linear sequence of reactions A B C D E F 75% 90% 80% 85% 70% Overall Yield: 32% A B C F 75% 90% 80% G D E 85% 70% Overall Yield from A: 54% Overall Yield from G: 48% Affect of Convergency on Overall EfFciency 5 Linear sequence of reactions A B C D E F 75% 90% 80% 85% 70%...
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SyntheticStrategy - Organic Synthesis Strategy Organic...

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