Urinary System III - Kidney Day : Review and Countercurrent...

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Kidney Day : Review and Countercurrent Mechanism Detailed
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Formation of Urine Figure 15.5
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Urine 95% H 2 O Urea catabolism of amino acids Uric acid catabolism of nucleic acids also Creatinine Trace amino acids Electrolytes NH 4
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Glomerular Filtration 1. H 2 O and various dissolved substances are forced out of the glomerular capillaries into the Bowman's Capsules. a. Glomerular capillaries are many times more permeable than ordinary capillaries - More permeable because of tiny openings ( fenestrae ) in their walls
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Glomerular Filtration The resulting Glomerular Filtrate: a. Received by Bowman's Capsule b. Mostly H 2 O c. Similar to blood plasma w/out large proteins H 2 O Na+ Cl- Glucose K+ HCO3- Amino acids Ca++ PO4- Urea SO4= Uric acid Creatine
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Glomerular Filtration Rate Forces Responsible: 1. Hydrostatic pressure of blood inside capillaries 2. Osmotic pressure of plasma in glomerulus (dissolved solutes) 3. Hydrostatic pressure of fluid in Bowman's Capsule
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Net pressure = Filtration Pressure glomerular Glomerular Capsular F.P. = hydrostatic - plasma + hydrostatic pressure osmotic pressure pressure
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Glomerular Filtration Osmotic pressure in glomerular plasma opposes hydrostatic plasma pressure As filtration occurs, proteins left in plasma cause a rise in osmotic pressure in glomerulus. When it reaches a high level, filtration stops Conversely, Factors that decrease plasma osmotic pressure cause increase in filtration rate. Fluids backing up in renal tubules causes hydrostatic pressure of Bowman's Capsule to rise; as in the case of blockage from stones or a swollen prostate. Rate of filtration decreases.
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Urinary System III - Kidney Day : Review and Countercurrent...

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