BSCI105, Freshman Connection Fall 2010 Study Guide #19 I. Regulation of Metabolism Vocabulary: Glyceraldehyde-3-phosphate Phosphofructokinase Homeostasis Citrate Isocitrate dehydrogenase Feedback Key Concept 1: Metabolic homeostasis depends on the coordination of metabolic pathways, such as glucose, protein and fatty acid metabolism, in response to cellular and energetic demands. Key Concept 2: Glucose is the preferred substrate for cellular respiration, but metabolic intermediates can be used that are derived from protein (pyruvate, acetyl CoA), other sugars (fructose-6-phosphate), and fatty acids (glyceraldehyde-3-phosphate, acetyl CoA). Key Concept 3: Glucose homeostasis regulations cellular respiration at several levels to balance utilization and storage in response to deficits or excesses in energy production. Key Concept 4: A key regulatory point early in glycolysis is the activity of the enzyme phosphofructokinase, which is a committed step in glucose catabolism.
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