14dna2 (1) - Lecture 14: DNA Replication Chapter 21:...

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Lecture 14: DNA Replication Chapter 21: Replication of DNA
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The Big Picture What is the exact mechanism of DNA replication ?
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3 Requirements of Genetics Genetic material must be able to: 1.) Store information 2.) Replicate 3.) Mutate
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The Goal of Replication When cells divide, each new cell needs an exact copy of the sequence of DNA base pairs
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DNA at Rest Before replication , DNA is: Double-stranded Twisted into a helix Super-coiled Wound around chromosomes
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Step 1: Unzipping Helicase enzyme works to unwind and “unzip” double-stranded DNA Like a zipper pull Breaks the weak hydrogen bonds between nitrogenous base pairs enzyme
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Step 1 of Replication http://www.youtube.com/ watch? v=0CMIgZQakHY
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Step 2: Complementary Pairs Free DNA nucleotides are present in the nucleus DNA polymerase: enzyme that builds new strand Uses old helix strands as templates for matching
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Notice! 1 old DNA double strand splits into 2 new ones Newly replicated DNA contains one strand of old nucleotides and one strand of new nucleotides Semi-conservative replication
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This note was uploaded on 12/08/2011 for the course PRE-HEALTH 1150 taught by Professor Profs during the Spring '11 term at Niagara College.

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14dna2 (1) - Lecture 14: DNA Replication Chapter 21:...

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