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Unformatted text preview: inadequate intake or insufficient absorption. Folate deficiency normally does not produce neurological symptoms, while B12 deficiency does. • Pernicious anemia is caused by a lack of intrinsic factor. Intrinsic factor is required to absorb vitamin B12 from food. A lack of intrinsic factor may arise from an autoimmune condition targeting the parietal cells (atrophic gastritis) that produce intrinsic factor or against intrinsic factor itself. These lead to poor absorption of vitamin B12. • Macrocytic anemia can also be caused by removal of the functional portion of the stomach, such as during gastric bypass surgery, leading to reduced vitamin B12/folate absorption. Therefore one must always be aware of anemia following this procedure. • Hypothyroidism • Alcoholism commonly causes a macrocytosis, although not specifically anemia. Other types of Liver Disease can also cause macrocytosis. • Methotrexate, zidovudine, and other drugs that inhibit DNA replication....
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- Fall '10
- Anthropology, Iron deficiency anemia, intrinsic factor, Macrocytic anaemia, Anemia of chronic disease, Hereditary sideroblastic anemia