Ankylosing spondylitis

Ankylosing spondylitis - Ankylosing spondylitis Ankylosing...

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Ankylosing spondylitis Ankylosing = fusion, Spondyl- = spine, -itis = inflammation. This is a chronic inflammatory disease of spine. Unknown aetiology but 95% of those affected are HLA B27 positive. Symptoms o Typical patient: <30y/o male, gradual onset, lower back pain, worse at night, with AM stiffness relieved by movement. o Pain at sacroiliac joints which speads to hips and buttocks On examination: Reduced spinal range of movement (hence reduced thoracic expansion) Question mark posture – neck hyper-extended and kyphosis Can also lead to enthesitis – inflammation of tendon/ligament insertion e.g. plantar fasciitis, Achilles tendonitis, costochondritis (may cause chest pain) Acute iritis – occurs in one third of patients, may cause blindness if left untreated Other associations: IBD, OP, aortic valve incompetence, pulmonary apical fibrosis. Causes Ankylosing spondylitis (AS) is a systemic Systemic disease rheumatic disease, meaning it affects the entire body. Approximately 90% of AS patients express the HLA-B27 genotype, meaning there is a strong
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Ankylosing spondylitis - Ankylosing spondylitis Ankylosing...

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