Antibiotics Aminoglycosides

Antibiotics Aminoglycosides - ContraIndications •...

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Antibiotics Aminoglycosides Aminoglycosides inhibit protein synthesis by causing incorrect reading of mRNA Not absorbed orally so must be given iv Active against many GRAM -ve and some GRAM +ve bacteria. Narrow therapeutic window – increased risk of toxicity as accumulate in renal impairment. Damage CNVIII ----- Ototoxicity Therefore need regular blood levels Impair Neuromuscular transmission so contraindicated in MG Gentamicin Indications: severe infection – sepsis, meningitis, endocarditis. Also pyelonephritis/prostatitis, biliary tract infecions, pneumonia. Route/Dose: 5-7mg/kg ivi. Side effects: Ototoxic Nephrotoxic Rarely colitis Nausea and vomiting Seizures MG like syndrome. Caution : Obesity Breast feeding Pregnancy Renal or hepatic failure.
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Unformatted text preview: ContraIndications: • Myasthenia Gravis Monitor : • Serum levels Interactions: • Increased effects by loop diuretics , vancomycin, cephalosporins, ciclosporin, tacrolimus – if must give these give doses as far from gentamicin as possible. • Increases effects of muscle relaxants and anticholinesterases. Strongly increases anticoagulation effects of warfarin . Tobramycin Streptomycin – active against TB. But due to ototoxic effects if used in prolonged/intensive therapy has been largely replaced by rifampicin. Neomycin – too toxic for parenteral use. Use topically in skin infections or orally to sterilise the bowel prior to surgery. Amikacin – use in serious GRAM -ve infections that are resistant to gentamicin....
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Antibiotics Aminoglycosides - ContraIndications •...

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