Antibiotics Tetracyclines

Antibiotics Tetracyclines - Antibiotics Tetracyclines...

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Tetracyclines Tetracyclines inhibit protein synthesis by blocking tRNA binding Usually given orally, but may be given by injection Absorption by gut reduced by calcium and magnesium (milk and antacid tablets). Broad spectrum but there are more appropriate drugs for many infections. Increasing resistance has reduced there usefulness. Good for intracellular organisms as penetrate macrophages well – chlamydia, Q-fever, lyme disease. Contraindicated in children <12, pregnancy and breast feeding as bind to calcium in growing bones causing tooth discolouration Tetracycline Indications: acne vulgaris and rosacea, genital/tropical infections Route/Dose: 500mg bd po – take >30mins before food Side effects: GI upset – rarely colitis Oesophageal irritation Headache Rarely hepatotoxicity and photosensitivity and visual changes. Contraindicated : Children <12 ( stains/deforms teeth ) Pregnancy Breast feeding Renal impairment. Caution
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Antibiotics Tetracyclines - Antibiotics Tetracyclines...

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