Autoimmune diseases

Autoimmune diseases - In rare cases, may cause anaphylactic...

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Autoimmune diseases cytotoxic T cells that target & destroy (self) body tissues - causes include improper negative selection of self-directed lymphocytes in bone foreign antigens that resemble self antigens multiple sclerosis (MS) to suppress lymphocyte activity Hypersensitivities: - Immediate hypersensitivities: o Type I (anaphylaxis): contact with allergen sensitizes individual; second contact results in immediate symptoms (swelling caused by IgE Produces symptoms of asthma - treated with antihistamines
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Unformatted text preview: In rare cases, may cause anaphylactic shock due to loss of blood plasma (hypotensive shock); can be fatal - treated with epinephrine Atopy : rarely symptoms may appear without initial sensitization- Subacute hypersensitivities: mediated b y IgG & IgM o Type II (cytotoxic) reactions: antibodies bind to antigens on cell surfaces (bacteria or foreign red blood cells) & stimulate phagocytes & complementmediated lysis (example: transfusion reactions) o Type III (immune complex) reactions: insoluble antigen-antibody complexes form resulting in intense inflammatory reaction (example: autoimmune diseases)- Delayed hypersensitivities: Kevin Kelleher, MTC Biology 211 Study Notes Exam 1 24 o Type IV reactions: slower to appear (1-3 days); mediated by T cells (cytotoxic & delayed hypersensitivity) (example: allergic contact dermatitis) page7...
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